课题负责人已结题项目：
1、国家“重大新药创制”科技重大专项：新人参二醇防治老年性痴呆的药学及生物学评价（2009ZX09103-365）146.3万元，2009/01-2010/12；
2、国家自然科学基金面上项目：新人参二醇药代动力学分析方法全确证的构建及在其代谢物分析中应用（31070308）35万元，2011/01-2013/12
3、吉林省科技人员服务企业行动项目：抗老年痴呆新药新人参二醇胶囊的研制（SQ2009GJB1002453）50万元，2009/01-2011/12
4、长春市科技局项目：抗老年痴呆新药新人参二醇的研制（08YJ41）10万元，2008/01-2009/12
Research Achievements:
Projects in charge that had been Completed:
1.NationalScience andTechnologyMajorProjects forNewDrugDevelopment: Pharmaceutical and Biological Evaluation of Neopanaxadiolfor The Prevention and Treatment of Senile Dementia (2009ZX09103-365) RMB1.463 million,2009/01-2010/12
2.General Program of The National Natural Science Foundation of China: Development of A Pharmacokinetic Analysis Method for Neopanaxadiol and Its Application in Metabolite Analysis (31070308) RMB 350,000, 2011/01-2013/12
3.Service Enterprise Action Program by Jilin Province Science and Technology Personnel: Research and Development of Neopanaxadiol Capsules for Alzheimer's Disease Treatment (SQ2009GJB1002453) RMB 500,000, 2009/01-2011/12
4.Changchun Municipal Science and Technology Bureau Project: Research and Development of Neopanaxadiol for Alzheimer's Disease Treatment (08YJ41) RMB 100,000, 2008/01-2009/12
代表性论文：Representative academic papers:
1.Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF-κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cells.J.Biochem.Mol.Toxicol.,34(2020)e22597.
2.2-Deoxy-Rh2: A novel ginsenoside derivative, as dual-targeting anti-cancer agent via regulating apoptosis and glycolysis.Biomed. Pharmacother.,124 (2020) 109891.
3.Development and validation of an UPLC-Q/TOF-MS assay for the quantitation of neopanaxadiol in beagle dog plasma: application to apharmacokinetic study.Biomed.Chromatogr., 31 (2017)e3878.
4.Structure identification of neopanaxadiol metabolites in rats by ultraperformance liquid chromatography/quadrupole-time-of-flighr mass spectrometry.Rapid commun. Mass spectrom.,29 (2015) 283-294.
5.A new ginsengenin containing an oxacyclopentane-ring isolated from the acid hydrolysate of total ginsenosides.Chin.Chem.Lett.,24(2013)524-526.
6.Anti-colon carcinoma cell activity of ginsenosides from the acid hydrolysate of Panax ginseng.Chem.Nat.Compd.,48 (2013)1017-1020.
7.Validated LC-ESI-MS/MS Method for the Quantitation of Neopanaxadiol: a Novel Neuroprotective Agent from Panax ginsengand Its Application to a Pharmacokinetic Study in Rat Plasma .Chromatographia,76(2013)509-514.
8.A new panaxadiol from the acid hydrolysate of Panax ginseng.Chin.Chem.Lett.,20(2009)687-689.
9.Analysis of quinolizidine alkaloids in Sophora flavescens Ait. by capillary electrophoresis with tris(2,2′-bipyridyl) ruthenium (II)-based electrochemiluminescence detection.Talanta,75(2008)38-42.
10.Facile separation and determination of Aconitine alkaloids in traditional Chinese medicines by CE withtris(2,2'-bipyridyl)ruthenium(II)-based electrochemiluminescence detection.Electrophoresis, 27(2006)4836-4841.
11.A Nonasaccharide Saponin from The Bark of Kalopanax septemlobus(Thunb.) Koidz.Chin.Chem.Lett.,16(2005)53-56.
